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Prisoners are more likely to have used drugs compared with the general population, and are exposed to various sources of higher risk like injecting, tattooing, unsafe sex. Many prisoners have complex health and social needs and assessment and treatment of drug related problems is important in prison. This highlights the role of the prison setting, in particular as a critical location for addressing problems for high-risk drug users. Significant considerable health and social gains can be won if a good prison care and support is linked with ensured continuation of service delivery.